Resistance of cancers to immune checkpoint blockades is frequently observed. Pancreatic cancer cells are now shown to create a tumor microenvironment that protects them from immunotherapy by overexpression of cytidine deaminase. This leads to increased production of uridine diphosphate that attracts immunosuppressive macrophages.
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Hofer, A. How tumors hijack macrophages for immune evasion. Nat Cancer 5, 1134–1135 (2024). https://doi.org/10.1038/s43018-024-00808-y
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DOI: https://doi.org/10.1038/s43018-024-00808-y
