Extended Data Fig. 6: The verification of cellular neighborhoods (CNs) and Tumor Patterns (TPs) in validation cohort.
a, The definition of the cellular neighborhood (CN) in validation cohort. Forty CNs were defined based on all cell types/phenotypes (CP-based-CNs) in the validation cohort. The annotation of the CNs was listed. The bar plot represented the composition of cell types in each CN. b, The comparison of CP-based-CNs between the validation and discovery cohorts. Heatmap showing the z-scored average cell type/phenotype percentage in each CN. The CNs in discovery cohort were annotated in orange whereas that in validation cohort were in green. c, Heatmap showing the hierarchical clustering of selected tumor phenotype-enriched CP-based-CNs and the z-scored percentage of CP-based-CNs in validation cohort. The left panel showed detailed annotations of defined TPs. n = 98. d, The Kaplan–Meier survival curves of TP_p53 vs other TPs in validation cohort. Log-rank tests were done to investigate the significance. TP-p53, n = 4; other TPs, n = 94. e, The schematic of the analysis pipeline of Fig. 5. For all panels, n denotes biologically independent samples.
