The early molecular events driving cancer initiation remain elusive, hampering prognostic accuracy. A comparative analysis of 3D genomics data from all stages of colon malignant transformation now reveals that altered connectivity of gene promoters with cognate enhancers is both predictive of and rate-limiting in neoplasia.
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References
Danieli, A. & Papantonis, A. Hum. Mol. Genet. 29, R197–R204 (2020).
Dubois, F., Sidiropoulos, N., Weischenfeldt, J. & Beroukhim, R. Nat. Rev. Cancer 22, 533–546 (2022).
Wang, X. & Yue, F. Curr. Opin. Genet. Dev. 86, 102199 (2024).
Zhu, Y. et al. Nat. Cancer https://doi.org/10.1038/s43018-024-00823-z (2024).
Goel, V. Y. & Hansen, A. S. Wiley Interdiscip. Rev. Dev. Biol. 10, e395 (2021).
Gryder, B. E. et al. Nat. Genet. 51, 1714–1722 (2019).
Liu, Y. et al. Cancer Res. 80, 5464–5477 (2020).
Sanalkumar, R. et al. Sci. Adv. 9, eabo3789 (2023).
Chakraborty, C. et al. Nat. Commun. 14, 6446 (2023).
Madsen, J. G. S. et al. Nat. Genet. 52, 1227–1238 (2020).
Murphy, D. et al. Nat. Struct. Mol. Biol. 31, 125–140 (2024).
Lovén, J. et al. Cell 153, 320–334 (2013).
Bushweller, J. H. Nat. Rev. Cancer 9, 611–624 (2019).
Johnstone, S. E. et al. Cell 82, 1474–1489 (2020).
Xie, T. et al. Nat. Commun. 15, 3905 (2024).
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Danieli-Mackay, A., Papantonis, A. A 3D genome view of colon cancer initiation. Nat Cancer 5, 1600–1601 (2024). https://doi.org/10.1038/s43018-024-00825-x
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DOI: https://doi.org/10.1038/s43018-024-00825-x
