Liquid–liquid phase separation has been shown to be involved in tumorigenesis. Phosphorylated HDAC6 is now found to form nuclear biocondensates that affect chromatin conformation and thereby gene expression, contributing to malignancy in triple-negative breast cancer.
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References
Thomas, A., Reis-Filho, J. S., Geyer, C. E. & Wen, H. Y. NPJ Breast Cancer 9, 55 (2023).
Garrido-Castro, A. C., Lin, N. U. & Polyak, K. Cancer Discov. 9, 176–198 (2019).
Lu, B. et al. Nat. Cancer https://doi.org/10.1038/s43018-024-00816-y (2024).
Nogués, L. et al. EBioMedicine 13, 132–145 (2016).
Bergman, J. A. et al. J. Med. Chem. 55, 9891–9899 (2012).
Kantidze, O. L. & Razin, S. V. Nucleic Acids Res. 48, 4614–4626 (2020).
Mehta, S. & Zhang, J. Nat. Rev. Cancer 22, 239–252 (2022).
Ahn, J. H. et al. Nature 595, 591–595 (2021).
Zeleke, T. Z. et al. Nat. Cancer 4, 257–275 (2023).
Banik, D. et al. Cancer Res. 80, 3649–3662 (2020).
Hey, J., Llamazares Prada, M. & Plass, C. Nat. Cancer 4, 156–158 (2023).
Médard, G. & Sheltzer, J. M. Nat. Cancer 4, 807–808 (2023).
Silva, J., Yu, J. & Kalinsky, K. Nat. Cancer 4, 809–811 (2023).
Sadar, M. D. Expert Opin. Drug Discov. 15, 551–560 (2020).
Zhong, L. et al. Signal Transduct. Target Ther. 6, 201 (2021).
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Benedetti, R., Altucci, L. Phase separation rewires chromatin in breast cancer. Nat Cancer 5, 1602–1604 (2024). https://doi.org/10.1038/s43018-024-00843-9
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DOI: https://doi.org/10.1038/s43018-024-00843-9
