Extended Data Fig. 6: Multiomic analysis of CD8+ T cells. | Nature Cancer

Extended Data Fig. 6: Multiomic analysis of CD8+ T cells.

From: TIGIT and PD-L1 co-blockade promotes clonal expansion of multipotent, non-exhausted antitumor T cells by facilitating co-stimulation

Extended Data Fig. 6

a, CD8+ T cell cluster composition by individual mice in each treatment group. Each color represents an individual mouse. Data show that no cluster came solely from a single animal or experimental group. b, Treatment group (Group) and tissue source projected on CD8+ T cell UMAP. c, Clone size and ADT counts projected on CD8+ T cell UMAP. In panels (b) and (c), n = 155,496 cells. d–f. CD8+ T cell marker expression measured by CITE-seq. d, Relative marker expression levels determined using CITE-seq antibodies projected on UMAPs comprised of CD8+ T cells from CT26 tumor, dLN and blood. e, Heatmap of relative CITE-seq marker expression levels in each CD8+ T cell cluster. f, Heatmap of relative CITE-seq marker expression levels in tissues under various treatment conditions.

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