Extended Data Fig. 7: Characterization of CD8+ T cell clusters.
a, Heatmap showing clusters defined using metadata from Li et al.24, where CD8T1 are likely naïve, CD8T2 has Tscm/memory properties, CD8T4 has activated effector cell properties, and CD8T5 has an exhausted phenotype. CD8T1 and CD8T2 were described as T cells that recently entered the tumor, while CD8T4 and CD8T5 were cells resident in tumor. CD8T2 also have the capacity to recirculate from tumor to dLN. b, RNA velocity projections on UMAPs for each treatment group in dLN (top) and tumour (bottom). c, UMAPs showing cluster composition in dLN (Lymph), tumor and blood from CT26 tumor-bearing mice treated with isotype control, anti-PD-L1, anti-TIGIT, combination, or combination with FTY720.
