Extended Data Fig. 10: Analyzing the effect of ULTR-p38i on healthy tissues in mice.
a, Hemoglobin concentration in mice treated for 4 d or 10w with 2015 or carrier (n = 4 mice per group, data are presented as mean values +/- SD, statistical significance was calculated using an ANOVA and Tukey’s multiple comparisons test, P = 0.0034). b-d, Determination of the mean corpuscular volume (MCV, b), the mean corpuscular hemoglobin (MCH, c) and the mean corpuscular haemoglobin concentration (MCHC, d) in mice treated for 4 d or 10w with 2015 or carrier (n = 4 mice per group, data are presented as mean values +/- SD, statistical significance was calculated using an ANOVA and Tukey’s multiple comparisons test, P < 0.005). e, Representative pictures of p38α stained colon tissue of patients (n = 8 patients). Scale bars, 200 µm. f,g, Cell viability analysis in SCC311 (f) and SCC321 (g) human colon organoids upon 4 d of treatment with 2015 or DMSO (n = 3 biologically independent experiments, data are presented as mean values +/- SD). The experiments in Extended Data Fig. 10f, g were independently performed three times and the stainings in Extended Data Fig. 10e were independently performed twice, all with similar results.
