Extended Data Fig. 6: Combination of RT with CAR T cell therapy in a syngeneic mouse glioma model.
Glioma was induced in mice by orthotopic transplantation with GL261 mouse glioma cells, followed by FLASH or standard RT and GD2 CAR-T cell therapy. a, Experimental procedures. b, Animal survival was monitored for 60 days (n = 10 mice). Statistical analysis by a two-tailed Log-rank Mantel-Cox test. c, Tumor volume was measured by bioluminescence imaging (n = 10 mice, mean ± SEM). Note: after standard RT plus CAR T cell treatment, one mouse developed neurological symptoms at late day 26 and was imaged at day 27. Statistical analysis by two-way ANOVA.
