Extended Data Fig. 8: The DD domain of MALT1 is essential for the induction of CSF1, PGE2 and CXCL1 expression in cancer cells. | Nature Cancer

Extended Data Fig. 8: The DD domain of MALT1 is essential for the induction of CSF1, PGE2 and CXCL1 expression in cancer cells.

From: Targeting both death and paracaspase domains of MALT1 with antisense oligonucleotides overcomes resistance to immune-checkpoint inhibitors

Extended Data Fig. 8: The DD domain of MALT1 is essential for the induction of CSF1, PGE2 and CXCL1 expression in cancer cells.The alternative text for this image may have been generated using AI.

a-c, Enzyme-linked immunosorbent assay (ELISA) analyses of CSF1 (a), PGE2 (b), and CXCL1(c) levels in the CM from E0771 cells expressing the indicated MALT1 mutants. Data represent mean ± SD. d-f, ELISA analyses of CSF1 (d), PGE2 (e), and CXCL1(f) levels in the CM from B16F10 cells expressing the indicated MALT1 mutants. Data represent mean ± SD. g-I, The relative mRNA levels of Csf1 (g), Ptges (h), and Cxcl1 (i) in 4T1 cells with the indicated MALT1 mutant expression. Data represent mean ± SD. j-l, The relative mRNA level of Csf1 (j), Ptges (k), and Cxcl1 (l) in MC38 cells with the indicated MALT1 mutant expression. Data represent mean ± SD. For a-l, n = 3 biological independent samples, one-way ANOVA with Dunnett’s multiple comparisons test.

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