Extended Data Fig. 6: Functional analysis of various clusters of CD19-BBz CAR-NK products.
a, Scatter plot (showing median and extremum) illustrating intergroup differences in subclusters (n = 2 for CR, 2 for PD, 3 for fCAR-NK). b, Differences were compared between CR + PD (n = 4) and fCAR-NK (n = 3). Data were illustrated as mean ± SEM. A two-sided student’s t-test was used. P = 0.035 (NK1), P = 0.004 (NK2), P = 0.0001 (NK3). c, Scatter plot (showing mean ± SEM) illustrating differences between CAR-NK products derived from male (XIST-, n = 3) and female (XIST + , n = 4). P values were calculated using a two-sided student t-test. P = 0.018. d, GSVA analysis based on gene expression levels of each subcluster, data source from Hallmarker (n = 2 for CR, 2 for PD, and 3 for fCAR-NK). e, Bar plot of KEGG enrichment analysis of DEGs of each subcluster (n = 2 for CR, 2 for PD, and 3 for fCAR-NK).
