Table 1 Baseline characteristics

From: Safety and feasibility of 4-1BB co-stimulated CD19-specific CAR-NK cell therapy in refractory/relapsed large B cell lymphoma: a phase 1 trial

Characteristics

Number of patients, % (n = 8)

Age (years)

˂60

1 (12.5%)

≥60

7 (87.5%)

Sex

Male

5 (62.5%)

Female

3 (37.5%)

History

DLBCL-GCB

1 (12.5%)

DLBCL-non-GCB

5 (62.5%)

MCL

1 (12.5%)

tFL

1 (12.5%)

Disease stage at study entry

I or II

3 (37.5%)

III or IV

5 (62.5%)

ECOG score

0

1(12.5%)

1

7 (87.5%)

IPI score

0–1

1 (12.5%)

2–3

5 (62.5%)

4–5

2 (25%)

LDH

<240

3 (37.5%)

≥240

5 (62.5%)

Extra nodal organ involvement

0

1 (12.5%)

<2

2 (25%)

≥2

5 (62.5%)

Number of previous lines of antineoplastic therapy

3

2 (25%)

4–8

6 (75%)

Refractory or relapse

Primary refractory

6 (75%)

Relapse

2 (25%)

Prior CD19 CAR T-cell therapy

CAR-T

3 (37.5%)

None

5 (62.5%)

  1. GCB, germinal center B-cell-like subtype; ECOG, Eastern Cooperative Oncology Group; IPI, international prognostic index; LDH, lactate dehydrogenase.