Extended Data Fig. 5: VHH expression alone does not alter tumor growth.
(a) VHH expression on wildtype or transduced MC38 and E0771 tumor cells. Data is representative of 2 independent experiments. (b) Tumor growth curves of wildtype MC38 (MC38-WT) or MC38 cells transduced to stably express VHH (MC38-VHH) without adoptive cell transfer of αVHH CAR T cells. n = 4 mice inoculated with MC38-WT and n = 3 mice inoculated with MC38-VHH. Two-way ANOVA, mean ± s.e.m. is depicted; n.s. = not significant (c) Tumor growth curves of wildtype E0771 (E0771-WT) or E0771 cells transduced to stably express VHH (E0771-VHH) without adoptive cell transfer of αVHH CAR T cells n = 4 mice inoculated with E0771-WT and n = 6 mice inoculated with E0771-VHH; Two-way ANOVA, mean ± s.e.m. is depicted; n.s. = not significant.
