Extended Data Fig. 8: Representative flow cytometric analysis images and the relative quantifications of IL-2@CaCPs.
From: Long-acting IL-2 release from pressure-fused biomineral tablets promotes antitumor immune response
a, Changes in the body weight over time; n = 9 mice in each group. b, Representative flow cytometric analysis images of CD103+ dendritic cells (DCs) gating on CD45+CD11c+ cells in the treated tumour. c,d, Representative flow cytometric analysis images (c) and relative quantification (d) of CD45+ cells in lymphocytes; n = 4 independent spleen samples from one experiment. e,f, Representative flow cytometric analysis images (e) and relative quantification (f) of CD3+ cells in CD45+ cells; n = 4 independent spleen samples from one experiment. g,h, Representative flow cytometric analysis images (CD8+ cells in CD3+ cells) (g) and relative quantification (h) of CD8+ cells in CD45+ cells; n = 4 independent spleen samples from one experiment. i, Representative flow cytometric analysis images of effector memory CD8+ T cells (CD8+CD62L−CD44+) and central memory CD8+ T cells (CD8+CD62L+CD44+). j, Degradation rate curve of IL-2@Ca(CO3)1/2(PO4)1/3 tablet within two months; n = 3 mice in each group. k, Data fitting of the degradation rate curve to estimate the degradation timeline of the crystallized tablet; n = 3 mice in each group. Statistical significance was calculated via one-way ANOVA with a Dunnett’s multiple comparisons test. In a,d,f,h,j,k, data are presented as mean ± s.d.
