Little is known about how mutations in genes encoding tumor suppressors influence metastatic site selection and whether sustained inactivation of such genes influences tumor maintenance at these sites. A new study shows that restoration of Smad4 expression in extant pancreatic metastases has anti-tumor effects in the liver but pro-tumor effects in the lungs.
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Gladstein, A.C., Feldser, D.M. Primary tumor chromatin landscape governs metastatic organotropism. Nat Cancer 6, 1755–1756 (2025). https://doi.org/10.1038/s43018-025-01048-4
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DOI: https://doi.org/10.1038/s43018-025-01048-4
