Extended Data Fig. 3: Anti-proliferative response to treatment in patient subgroups. | Nature Cancer

Extended Data Fig. 3: Anti-proliferative response to treatment in patient subgroups.

From: Evaluating progesterone receptor agonist megestrol plus letrozole for women with early-stage estrogen-receptor-positive breast cancer: the window-of-opportunity, randomized, phase 2b, PIONEER trial

Extended Data Fig. 3

A) Geometric means of proportional change in Ki67 in control (Arm A, n = 51 patients) vs megestrol combination treatment (Arms B + C, n = 145 patients) across different PR expression levels (Allred score, 0-3 (n = 44 patients), 4-6 (n = 35 patients), 7-8 (n = 117 patients)). Error bars are 95% CI. B) Boxplot of baseline vs EOT Ki67 (%) in subgroups with different PR expression levels (Allred score) in Arm A (n = 51 patients) vs B + C (n = 145 patients). Box = IQR, centre = median, whiskers = min/max (excluding outliers, defined as <Q1 – 1.5*IQR or > Q3 + 1.5*IQR).

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