Extended Data Fig. 3: β-catenin is constitutively phosphorylated and poised for degradation in B-lymphoid cells. | Nature Cancer

Extended Data Fig. 3: β-catenin is constitutively phosphorylated and poised for degradation in B-lymphoid cells.

From: Targeting β-catenin degradation with GSK3β inhibitors induces cell death in acute lymphoblastic leukemia

Extended Data Fig. 3

Non-phosphorylated β-catenin and β-catenin phosphorylated on N-terminal by GSK3B (pS37) were visualized by immunohistochemistry (brown, counterstain hematoxylin) on tissue microarrays from epithelial cancers, including colon cancer (n = 13 tumors, biological replicates), lung cancer (n = 41 tumors, biological replicates), breast cancer (n = 58 tumors, biological replicates), as well as B-lymphoid malignancies, including mantle cell lymphoma (n = 21 tumors, biological replicates), follicular lymphoma (n = 54 tumors, biological replicates), DLBCL (n = 47 tumors, biological replicates) and Hodgkin’s lymphoma (n = 20 tumors, biological replicates). Representative images are shown.

Back to article page