Activation of cytosolic nucleic acid sensors in tumor cells is an important early step for initiating antitumor immunity, but the mechanisms controlling their activity are not fully understood. Using an in vivo CRISPR screen, CDK10 is now revealed as a cancer cell-intrinsic driver of immune evasion that limits production of immunostimulatory nucleic acids.
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N.S.F. and N.R.W. are employees of Genentech. This commentary reflects the personal views of the authors and should not be considered to represent the opinions of Genentech or The Roche Group.
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Firmino, N.S., West, N.R. CDK10 inhibits innate sensing to constrain antitumor immunity. Nat Cancer (2026). https://doi.org/10.1038/s43018-025-01101-2
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DOI: https://doi.org/10.1038/s43018-025-01101-2
