Extended Data Fig. 1: Patient inclusion in endpoint analyses.

This alluvial diagram depicts the inclusion or exclusion of patients in the analysis of each study endpoint (x-axis). Patients that were treated with pembrolizumab were included in the analysis regarding that pathological complete response (pCR) rates. Patients that were treated with pembrolizumab and underwent surgery were included in the analysis for the relapse-free survival (RFS) rate. Patients that were treated with pembrolizumab and had measurable disease were included in the analysis for clinical response, even if they were not assessed by imaging at 9 weeks.