Table 5 Antibiotic susceptibility (mg/L) of the different strains used in this study against LNZ and LEV alone or in combination

From: Bilayer sol-gel system for local prevention in prosthetic joint infections and osteointegration improvement

Strain

MICLNZ

MICLEV

MICLNZ+LEV

MICLEV+LNZ

FIC index

FIC index interpretation

S. aureus ATCC 29213

0.75 (S)

0.125 (I)

0.75

0.125

2

Indifference

S. epidermidis ATCC 35984

0.5 (S)

0.125 (I)

0.125

0.032

0.5

Synergy

E. coli ATCC 25922

>256 (R)

0.64 (I)

ND

ND

ND

ND

P. aeruginosa ATCC 27953

>256 (R)

1 (I)

ND

ND

ND

ND

  1. S susceptible, I intermediate or susceptible to high-concentration treatment, R resistant. Note: the phenotype was determined using the EUCAST Clinical Breakpoints (v 15.0). ND not determined.
Back to article page