Fig. 4: RNA-seq analysis reveals the potential pro-healing mechanism of EDPP.
From: Transforming pomelo peel waste into multifunctional biomaterials for hemostasis and wound healing
A Principal component analysis (PCA) of samples from the EDPP and PELNAC groups. B A volcano plot shows the up-regulated and down-regulated genes in the EDPP group compared to the PELNAC group. C A heatmap displaying the top 10 up-regulated and down-regulated genes in the EDPP group relative to the PELNAC group. GO enrichment analysis highlighting positive regulation of immune response (D), anti-inflammatory processes (E), and wound healing (F) in the EDPP group compared to the PELNAC group. G, H Representative gene set enrichment analysis (GSEA) comparing the EDPP and PELNAC groups. I GO enrichment analysis related to the negative regulation of inflammation in the EDPP group compared to the PELNAC group. J Protein-protein interaction networks of immune responses regulated by EDPP. K The schematic illustrates how EDPP mitigates the pro-inflammatory response by promoting M2 macrophage polarization, thereby creating a favorable wound bed for repair.
