Fig. 1: Analysis of the dose–response curves of SARS-CoV-2 NAbs.
From: Modeling how antibody responses may determine the efficacy of COVID-19 vaccines
a, Fits (lines) of the median-effect equation to published experimental data (circles) of the fraction of infection events blocked (fa) as a function of NAb concentration, shown for two NAbs, BD-236 (left) and 47D11 (right). Experimental data points with 1% < fa < 99% (circles) were considered for parameter estimation. Fits for the remaining NAbs are provided in Supplementary Fig. 2. fu and fa are the fraction of infection events that are unaffected and affected respectively, by the NAbs in a single round of infection. b,c, The best-fit estimates of IC50 (b) and m (c) for all the NAbs analyzed (Supplementary Data 1).
