Extended Data Fig. 2: Comparison of ancestor-descendant (AD) accuracy measures for HUNTRESS, PhISCS-BnB, ScisTree and SPhyR on simulated data with no false positives.
From: Fast intratumor heterogeneity inference from single-cell sequencing data
Here n, m and fn, respectively, denote the number of cells, the number of mutations and the false negative error rate in single-cell sequencing. For each setting of n and m, we report the ancestor-descendent (AD) accuracy measure for each tool with respect to the ground truth. The experiments were performed over 10 distinct trees of tumor progression, using a false negative error rate of 0.05, 0.1 or 0.2. Each tool was run with a time limit of 8 hours (those cases that exceed the time limit are not included here). Note that we have not included results of PhISCS-I and PhISCS-B as their accuracy values are identical to that of PhISCS-BnB (on these instances on which they completed the task) due to the same underlying objective function and optimality guarantee that they all provide.
