Extended Data Fig. 7: Dominant ALS progression patterns, identified using length-scale and negative mean function slope.
From: Identifying patterns in amyotrophic lateral sclerosis progression from sparse longitudinal data
Length-scale indicates trajectory stability; negative mean function slope corresponds to rate of progression. Learned model parameters from the PRO-ACT reference model are k-means clustered (Left plot; k=6, marker size corresponds to cluster size), with clusters ≥ N=5 visualized, and percentage of individuals that fall within each of the trajectory patterns are labeled (Right plots).
