Fig. 6: Estimating EZN from SEEG stimulation for a second patient with frontal lobe epilepsy (synthetic data).
a, Top: PM’3-4 (large blue/red sphere) is the stimulated contact in the left frontal lobe, using a bipolar pulse stimulation (50 Hz for a duration of 3 s with pulse duration 1 ms). Bottom: spatial map showing the amplitude of electric field (shown in the color bar from low (left) to high (right) values) at each brain vertex, induced by SEEG stimulation (from sensor PM’3-4). b, Seizure dynamics were simulated using the Epileptor-Stimulation model and induced through SEEG stimulation. Neural source activity in arbitrary units (a.u.) is shown on the cortical mesh at five different time points, with values indicated by color. c, Selected simulated SEEG time series (top) and EEG time series (bottom) from SEEG-stimulation-induced seizure. The scaled-up time series during the seizure period are shown in red. d, Posterior distribution of EVs (higher value indicates higher chance for seizure) for eight selected regions obtained from the HMC sampling when analyzing simultaneously SEEG and scalp-EEG. SMA, supplementary motor area. e, The highest chance of being the EZN as left F1 lateral prefrontal in red mapped in the 3D brain and left F1 mesial prefrontal cortex and left-middle frontal sulcus in yellow.
