Extended Data Fig. 1: Next-generation sequencing technology and third-generation sequencing technology.
From: Real-time raw signal genomic analysis using fully integrated memristor hardware
a, Previous high-throughput next-generation sequencing technologies relied on large devices due to optical principles. Analyzing the reads required substantial memory, often necessitating powerful servers in large laboratories. b, Current third-generation sequencing technologies have moved sequencing to the edge, utilizing current sensing principles. However, the signals are small and susceptible to noise, making analysis complex and also performed in laboratories. c, In-memory computing is a strong candidate for memory bottleneck genomic analysis. With in-memory computing hardware, such as crossbar and CAM, real-time analysis can be achieved with high speed and energy efficiency at the edge. Credit: icons, Flaticon (https://www.flaticon.com/).
