Table 2 Targets for assessing the biological activity of Macrovipera crude venoms
142Target | M. l. lebetina | M. l. cernovi | M. l. obtusa | M. l. turanica | M. schweizeri | References | |
|---|---|---|---|---|---|---|---|
Human | |||||||
CaCo-2 (colon adenocarcinoma) | ✓ | ||||||
HEK293T (Human Embryonic Kidney 293 variant) | ✓ | ✓ | ✓ | ✓ | |||
HUVEC (Human Umbilical Vein Endothelial Cells) | ✓β, γ | ✓γ | ✓α, β,γ | ✓γ | ✓γ | ||
K562 (chronic myelogenous leukaemia) | ✓ | ||||||
MCF-7 (breast cancer) | ✓ | ||||||
MDA-MB-231 (breast cancer) | ✓ | ✓ | ✓ | ✓ | |||
U-87 MG (malignant glioblastoma) | ✓ | ||||||
Plasma | ✓ | ✓ | ✓ | ✓ | ✓ | ||
nAChR (nicotinic acetylcholine receptor) mimotopes | ✓ | ✓ | ✓ | ✓ | ✓ | ||
Monkey | |||||||
Vero (Chlorocebus sabaeus kidney) | ✓ | ||||||
Mouse | |||||||
L929 (fibroblast cells) | ✓ | ||||||
RAW264.7 (macrophage) | ✓ | ✓ | ✓ | ✓ | |||
Liver, kidney, lung, and heart tissues | ✓ | ||||||
Rat | |||||||
Neonatal cardiomyocytes and nonmyocytes | ✓ | ||||||
Atria and perfused mesenteric bed | ✓ | 145* | |||||
Paw oedema model | ✓ | ||||||
Guinea pig | |||||||
Ileum | ✓ | 145* | |||||
Gram-positive bacteria | |||||||
Bacillus cereus ATCC 7064 | ✓ | ||||||
Enterococcus faecalis ATCC 29212 | ✓ | ||||||
Enterococcus faecium DSM 13590 | ✓ | ||||||
Staphylococcus aureus ATCC 25923 | ✓β | ✓α,β | ✓β | ✓β | |||
Staphylococcus epidermidis ATCC 12228 | ✓β | ✓α,β | ✓β | ✓β | |||
Listeria monocytogenes DSM 20600 | ✓ | ✓ | ✓ | ✓ | |||
Gram-negative bacteria | |||||||
Escherichia coli ATCC 25922 | ✓β | ✓α,β | ✓β | ✓β | |||
Escherichia coli 0157:H7 | ✓ | ||||||
Proteus vulgaris ATCC 6957 | ✓ | ||||||
Salmonella typhimurium CCM 5445 | ✓ | ||||||
Fungi | |||||||
Candida albicans ATCC 10239 | ✓ | ||||||
Artificial | |||||||
Giant unilamellar vesicles (GUV) | ✓ | ||||||
