Soft bioelectronics promise seamless human–machine integration but typically struggle to maintain reliable functionalities under long-term exposure to the body’s dynamic environment. Identifying the full spectrum of failure modes, while implementing multidimensional strategies to enhancing long-term stability, is key to achieving clinical-grade stability.
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Acknowledgements
This work was supported by the start-up fund and the seed grant from the Center for Precision Engineering for Health at the University of Pennsylvania.
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Ye, Y., Jiang, Y. Engineering long-term stability in soft bioelectronics for clinical translation. Nat Rev Bioeng (2026). https://doi.org/10.1038/s44222-026-00414-w
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DOI: https://doi.org/10.1038/s44222-026-00414-w
