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A universal membrane-centric mechanotransduction mechanism for vibrationally stimulated cells

Nature Reviews Bioengineering (2026)Cite this article

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Cells can respond to vibrational frequencies beyond physiological frequency ranges, including those in the ultrasonic domain. Independent, standardized experiments that probe mechanotransduction across frequencies and vibration modalities could clarify the underlying mechanisms that enable this broadband responsiveness.

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Fig. 1: Membrane mechanotransduction mechanism in response to cells subjected to mechanostimulation with surface reflected bulk waves.

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Acknowledgements

L.Y.Y. is grateful for funding from the Australian Research Council through Discovery Grant DP210101720.

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Authors and Affiliations

  1. Micro/Nanophysics Research Laboratory, School of Engineering, RMIT University, Melbourne, Victoria, Australia

    Lizebona August Ambattu & Leslie Y. Yeo

  2. Complex Tissue Regeneration Department, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht, the Netherlands

    Lorenzo Moroni

Authors
  1. Lizebona August Ambattu
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  2. Lorenzo Moroni
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  3. Leslie Y. Yeo
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Corresponding author

Correspondence to Leslie Y. Yeo.

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The authors declare no competing interests.

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Inaugural workshop on sonomechanobiology: https://www.lorentzcenter.nl/sonomechanobiology-understanding-high-frequency-mechanostimulation.html

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Ambattu, L.A., Moroni, L. & Yeo, L.Y. A universal membrane-centric mechanotransduction mechanism for vibrationally stimulated cells. Nat Rev Bioeng (2026). https://doi.org/10.1038/s44222-026-00420-y

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