Fig. 5: MD simulation—altered penetration and H-bonding distribution in synergistic combinations of W2 and WF1a inserting into POPE/POPG bilayers.
From: Synergy between Winter Flounder antimicrobial peptides
Centre of mass analysis where each point is one peptide in one of three replicate simulations, the bar is the mean and error is SE (a). Sideview snapshot for WF1a/pleurocidin after 200 ns (c). Lipid acyl chain order parameters for lipids within 4 Å of a peptide shown as averages of the three replicates for POPE (b) or POPG (d) in mixed POPE/POPG bilayers. Hydrogen bonding distribution for WF1a (e, f) or WF2 (g, h) run unmixed (e, g) or as combinations (f, h). Each panel is a sum of four peptides when the peptides are unmixed or two peptides each for the combinations and is representative of n = 3 replicates. Two-way ANOVA with Šídák’s multiple comparisons test: **p < 0.01.
