Table 2 Antimicrobial activity.

Isolate	WF1	WF1a	WF1a-1	WF2 (pleurocidin)	WF3	WF4
Gram-negative
Klebsiella pneumoniae NCTC 13368	32	128	4	4–8	64	16
Klebsiella pneumoniae M6	16	128–>128	4	2–8	64	16–32
Acinetobacter baumannii AYE	4–8	16–32	2	2–4	16	2-4
Acinetobacter baumannii ATCC 17978	4–8	16–32	1	2	8–16	2-4
Pseudomonas aeruginosa PAO1	128	>128	2	8–16	>128	64–128
Pseudomonas aeruginosa NCTC 13437	128	>128	4–8	16	>128	128
Pseudomonas aeruginosa RP73	>128	128	8	32	>128	128
Escherichia coli NCTC 12923	4–8	32	1–2	1	8–16	2–4
Vibrio parahaemolyticus NCTC 10903	16	32	0.25	0.5	16	2
Vibrio vulnificus NCTC 13647	32	32	2	1	32	4
Gram-positive
MS Staphylococcus aureus ATCC 9144	32	128	4–8	2–4	8–32	16–32
EMR Staphylococcus aureus-15 NCTC 13616	128	>128	8–16	16	8–16	>128
EMR Staphylococcus aureus-16 NCTC 13277	128	>128	8–16	4	16–32	128
VS Enterococcus faecalis NCTC 775	128	128–>128	128	32–64	64–128	128
VR Enterococcus faecalis NCTC 12201	128–>128	>128	128	32	128	128
VR Enterococcus faecium NCTC 12204	128	128	16–32	2–4	32	32–64

Minimal inhibitory concentrations (µg/ml) are given for peptides tested in Mueller–Hinton broth. Italic or bold values indicate, respectively, a significant (factor of >2) reduction or improvement in potency relative to pleurocidin. Modal values are presented from three independently replicates.
MS methicillin sensitive, EMR epidemic methicillin resistant, VS vancomycin sensitive, VR vancomycin resistant.

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