Table 4 Prevalence of antimicrobial potency synergy in binary combinations of WF AMPs.
From: Synergy between Winter Flounder antimicrobial peptides
Combination | EMRSA-15 NCTC 13616 | K. pneumoniae NCTC 13368 | A. baumannii AYE | |||
|---|---|---|---|---|---|---|
FIC (mean ± SEM) | MICs (µg/ml) | FIC (mean ± SEM) | MICs (µg/ml) | FIC (mean ± SEM) | MICs (µg/ml) | |
WF1/WF1a | 1.50 | 128/128 | 1.00 | 16/64 | 0.50 | 2/8 |
WF1/WF1a-1 | 0.50 | 32/2 | 1.00 | 16/2 | 0.50 | 2/0.5 |
WF1/WF2 | 0.19 ± 0.06 | 8/0.25–16/0.5 | 0.31 | 8/0.25 | 0.50 | 2/0.5 |
WF1/WF3 | 0.19 ± 0.06 | 8/0.5–16/1 | 0.50 | 8/16 | 0.25 | 1/2 |
WF1/WF4 | 2.00 | 128/128 | 0.75 | 16/4 | 0.75 ± 0.25 | 2/1 - 4/2 |
WF1a/WF1a-1 | 0.38 | 32/2 | 0.25 | 16/0.5 | 0.25 | 4/0.25 |
WF1a/WF2 | 0.19 | 16/0.5 | 0.13 | 8/0.25 | 0.25 | 4/0.25 |
WF1a/WF3 | 0.19 | 16/1 | 1.00 | 64/32 | 0.50 | 8/4 |
WF1a/WF4 | 1.50 | 128/128 | 1.00 | 64/8 | 0.50 | 8/1 |
WF1a-1/WF2 | 1.50 ± 0.5 | 4/2–8/4 | 1.00 | 2/2 | 1.00 | 1/1 |
WF1a-1/WF3 | 1.00 | 4/4 | 0.50 | 1/16 | 0.19 ± 0.06 | 0.125/1–0.25/2 |
WF1a-1/WF4 | 2.00 | 8/128 | 1.50 ± 0.5 | 2/8–4/16 | 1.00 | 1/2 |
WF2/WF3 | 1.00 | 2/4 | 0.25 | 0.5/8 | 0.25 | 0.25/2 |
WF2/WF4 | 0.25 | 0.5/16 | 1.00 | 2/8 | 0.50 | 0.5/1 |
WF3/WF4 | 1.00 | 4/64 | 0.25 | 8/2 | 0.19 ± 0.06 | 1/0.25–2/0.5 |
