Table 5 Survival of ATCC 17978 burn wound-infected Galleria mellonella.

From: Synergy between Winter Flounder antimicrobial peptides

Condition

Survival % @ 96 h

p value

Log-rank (Mantel–Cox) test

Gehan–Breslow–Wilcoxon test

Burn only

95.0

<0.0001

<0.0001

Gentamicin 5 mg/kg

86.7

0.0006

0.0013

Ciprofloxacin 5 mg/kg

80.0

0.0017

0.0009

Imipenem 5 mg/kg

70.0

0.0169

0.0084

Meropenem 5 mg/kg

70.0

0.0419

0.0488

WF2 (pleurocidin) 20 mg/kg

60.0

0.2082

0.2633

WF2 (pleurocidin) 10 mg/kg

86.7

0.0004

0.0004

WF2 (pleurocidin) 2.5 mg/kg

63.3

0.0897

0.0813

WF1a 50 mg/kg

53.3

0.5844

0.6668

WF2 2.5 mg/kg/WF1a 50 mg/kg

86.7

0.0002

0.0001

WF3 20 mg/kg

60.0

0.3653

0.6120

WF2 2.5 mg/kg/WF3 20 mg/kg

86.7

0.0005

0.0009

WF4 5 mg/kg

66.7

0.1091

0.1984

WF3 20 mg/kg/WF4 5 mg/kg

100.0

<0.0001

<0.0001

  1. Significance tests are versus burn and infection where survival at 96 h is 46.0%. Conditions where significant (p < 0.05) protection is afforded by the treatment are highlighted in bold. Burn only and burn + infection n = 50, all treatment groups n = 30.
Back to article page