Fig. 5: Adaptive laboratory evolution and characterisation of antibiotic resistance in K. pneumoniae CFE. | npj Antimicrobials and Resistance

Fig. 5: Adaptive laboratory evolution and characterisation of antibiotic resistance in K. pneumoniae CFE.

From: A cell-free strategy for host-specific profiling of intracellular antibiotic sensitivity and resistance

Fig. 5: Adaptive laboratory evolution and characterisation of antibiotic resistance in K. pneumoniae CFE.The alternative text for this image may have been generated using AI.

a Real-time protein synthesis of mScarlet (μM) for the wild type (WT), RifR and ChlR mutants. b, c IC50 data of two biological repeats for the RifR mutant plotted separately versus a representative dataset for the WT in response to rifampicin dosing. CFE data for WT is the mean and standard deviation of two independent experiments. d, e IC50 data of two independent extracts for the ChlR mutant plotted separately versus a representative dataset for the WT in response to chloramphenicol dosing. CFE data is presented as a mean and standard deviation of three measurements from each extract.

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