Fig. 3: Mutation profile of trimethoprim-resistant derivatives.

Schematic representation of the single nucleotide polymorphisms, insertions and deletions found in the chromosome of trimethoprim-resistant derivatives relative to their individual ancestor clinical isolate. Ring colours indicate the ancestor clinical isolate and their linked trimethoprim-resistant derivatives; UTI-34 (a, purple), UTI-39 (b, green) and UTI-59 (c, yellow). Filled circles represent coding, non-synonymous mutations; open circles represent coding, synonymous or intragenic mutations; filled triangles represent multiple synonymous or non-synonymous mutations; open square represents intragenic indels; asterisk represent folA coding and promoter region mutations and circle with cross represents folA promoter region mutations only.