Fig. 3: Expression of vraXpro-lux and the growth curve induced by tunicamycin and Tarocin A. | npj Antimicrobials and Resistance

Fig. 3: Expression of vraXpro-lux and the growth curve induced by tunicamycin and Tarocin A.

From: Design, synthesis and optimization of TarO inhibitors as multifunctional antibiotics against Methicillin-resistant Staphylococcus aureus

Fig. 3

Data from n = 2 biological replicates and reported as the mean ± SD. A, B Expression of vraXpro-lux induced by different concentrations of tunicamycin and Tarocin A, respectively. C, D Enlarged figure of (A) and (B) for the first five hours after induction. E, F The corresponding growth curve treated by tunicamycin or Tarocin A. Growth curve of a tarO null mutant of USA300 LAC strain was also illustrated as a positive control, and the black arrow indicated the time at which OD600 was recorded and used for IC50 calculation. In (E) and (F), data from WT control and the isogenic ΔtarO strain was derived from the same two biological replicates, respectively.

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