Fig. 8: Survival curves of Galleria mellonella larvae infected with MRSA HS663 strain. | npj Antimicrobials and Resistance

Fig. 8: Survival curves of Galleria mellonella larvae infected with MRSA HS663 strain.

From: Design, synthesis and optimization of TarO inhibitors as multifunctional antibiotics against Methicillin-resistant Staphylococcus aureus

Fig. 8

A The impact of administering 18a or imipenem alone on the survival rate of Galleria mellonella larvae infected; at a dose of 1.5 × 106 CFU. MIC of imipenem against HS663 was 64 μg/mL. B Impact of administering 18a or imipenem alone or in combination on the survival ability of Galleria mellonella larvae infected with HS663 at a dose of 2.0 × 106 CFU. For each group, eighteen larvae were included and the survival/deaths of the larvae was observed d every 12 h for 5 days. *P < 0.05, **P < 0.01, ***P < 0.001, by log-rank test.

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