Scheme 2
Reagents and conditions: (V) acrylic anhydride, LiCl, Et3N, THF, rt, 6 h, 54%; (VI) Michael donors, NaH (or Et3N for 19), DMF, rt, 0.5 h, 20–32%.
Scheme 2 | npj Antimicrobials and Resistance
Reagents and conditions: (V) acrylic anhydride, LiCl, Et3N, THF, rt, 6 h, 54%; (VI) Michael donors, NaH (or Et3N for 19), DMF, rt, 0.5 h, 20–32%.
