Fig. 2: Identification of the Trp85Arg SNP in xthA as a Significant Marker of Antibiotic Resistance. | npj Antimicrobials and Resistance

Fig. 2: Identification of the Trp85Arg SNP in xthA as a Significant Marker of Antibiotic Resistance.

From: Genome wide analyses reveal the role of mutator phenotypes in Mycobacterium tuberculosis drug resistance emergence

Fig. 2

A Null Distributions of TreeWAS Scores: This panel displays the null distributions of simulated SNP associations for the three TreeWAS scores: terminal, simultaneous, and subsequent. The Trp85Arg SNP in xthA (nucleotide positions 252 and 253) surpasses the significance threshold in all three distributions, strongly indicating its association with antibiotic resistance. B Manhattan Plots of SNP Associations: These plots visualize the distribution of SNP associations across amino acid positions in genes, with the red line representing the significance threshold. SNPs exceeding this threshold, including the Trp85Arg variant, are highlighted to emphasize their significance. The colors of the data points were randomly assigned to differentiate SNPs across the three TreeWAS scores.

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