Fig. 4: Ternary optimization for selection of three antibiotics.
From: Computational framework for streamlining the success of sequential antibiotic therapy
For three antibiotics, 2,024 different combinations are analyzed, corresponding to all (100%) possible combinations. A Antibiotics Aztreonam (AZE), Azithromycin (AZY), and Colistin (COL) are one solution exhibiting the highest level of collateral sensitivity, following a target given by 100% of collateral sensitivity. B Meropenem (MER), Aztreonam (AZE), and Carbenicillin (CAR) is among the solutions exhibiting the highest level of cross-resistance, following a target of 100% cross-resistance. C.Aztreonam (AZE), Amikacin (AMI), and Imipenem (IMI) are one solution exhibiting the highest level of insensitive, with a target given by 100% insensitive. D Colistin (COL), Carbenicillin (CAR), and Aztreonam (AZE) follow the target given by 50% collateral sensitivity and 50% cross-resistance. E Meropenem (MER), Aztreonam (AZE) and Amikacin (AMI) follow the target given by 50% cross-resistance and 50% insensitivity. Finally, F Ticarcillin (TIC), Fosfomycin (FOS), and Azithromycin (AZY) follow the target given by 50% collateral sensitivity and 50% insensitivity. The inset displays the total of 2,024 combinations for a three-drug therapy, of which 1485 combinations (73.3%) are associated with therapeutic failure, leaving only 539 cases to analyze their success. The shaded area represents the proximity of the solution to the target, red if the solution corresponds to therapy failure and blue otherwise.
