Fig. 4: Growth inhibition is not essential for survival against ampicillin.

Comparison of pre-exposure growth rates between non-survivors and survivors in M9 (a) or in M9+40X αMG (b). Each symbol depicts the pre-ampicillin growth rate of individual CFT073 cell and red bars indicate median ± 95% confidence intervals; asterisks (***) indicate significance (p < 0.0001, Mann–Whitney test). Relative frequency distribution of pre-exposure growth rates of non-survivors (white) and survivors (gray/blue), grown in M9 (c) or in M9+40X αMG (d). Correlation between pre-exposure growth rate and lysis rates amongst non-survivors cultured in M9 (e) or in M9+40X αMG (f). Each symbol represents a single-cell. The red-line represents the linear fit. The computed Spearman correlation coefficient value (r) is shown.