Table 2 CRC-risk SNPs or genes associated with survival.

From: Relationship between 233 colorectal cancer risk loci and survival in 1926 patients with advanced disease

SNP/Gene

Locus

Minor allele

Genes

Additive model

Recessive model

HR

95% CI

P

HR

95% CI

P

rs11255841

10p14

A

RNA5SP299

0.88

0.81–0.95

1.7 × 10−3

0.85

0.77–0.94

2.0 × 10−3

rs16892766

8q23.3

C

EIF3H, LOC105375713

1.2

1.06–1.36

4.0 × 10−3

1.28

0.95–1.73

0.1

rs117079142

8q24.11

A

EIF3H, UTP23

1.26

1.07–1.48

6.0 × 10−3

2.79

1.70–4.58

4.7 × 10−5

rs4444073

11p15.4

C

CAND1.11, ADM, LOC653503, SBF2

1.11

1.03–1.20

7.0 × 10−3

1.01

0.94–1.07

0.87

rs9924886

16q22.1

C

CDH3, CDH1, HSPE1P5, RNA5SP429

1.12

1.03–1.23

1.1 × 10−2

1.24

1.12–1.38

5.2 × 10−5

rs280097

4q22.2

C

 

1.1

1.02–1.19

1.4 × 10−2

1.08

1.01–1.15

3.5 × 10−2

rs1497077

14q22.1

T

NID2, RTRAF

1.1

1.02–1.19

1.7 × 10−2

1.12

1.03–1.21

7.2 × 10−3

rs13086367

3q13.2

G

BOC, LINC02044

0.92

0.86–1.00

4.4 × 10−2

0.95

0.89–1.01

0.12

EPB41L2

6q23.2

-

-

-

-

2.6 × 10−3

-

-

-

ADAMTS15

11q24.3

-

-

-

-

1.7 × 10−2

-

-

-

F2

11p11.2

-

-

-

-

3.2 × 10−2

-

-

-

  1. Risk SNPs or genes nominally associated with survival (P < 0.05) under an additive model. Genes annotated within a region spanning 50 kb up or downstream of the SNP. Only rs117079142 and rs9924886 passed the threshold for multiple testing (P < 2.1 × 10−4) when considered under a recessive model (in bold).
Back to article page