Table 1 Population demography with personal and family history of cancer.

From: Founder pathogenic variants in colorectal neoplasia susceptibility genes in Ashkenazi Jews undergoing colonoscopy

  

Number

%

Source of constitutional DNA (n = 765

    - Adenoma

 

200

26,1%

    - Blood

 

259

33,9%

    - Tumor

 

3

0,4%

    - Hyperplasia

 

53

6,9%

    - Normal Mucosa

 

249

32,5%

    - Other

 

1

0,1%

Sex (n = 765)

    - Female

 

323

42,2%

    - Male

 

442

57,8%

Age at diagnosis

   Mean

 

66,7

 

   Median

 

69

 

Personal history (n = 765)

 

- Polyps only

492

64,3%

 

- Polyps & Colon Cancer

85

11,1%

 

- Polyps & Rectal Cancer

11

1,4%

 

- Polyps & Metachronous Colon Cancer

5

0,7%

 

- Polyps & Rectal & Colon Cancers

2

0,3%

 

- Polyps & Desmoid tumor

1

0,1%

 

- Healthy – no colorectal tumors

165

21,6%

 

- Unknown – could not verify colon status

4

0,5%

Familial history (first degree relative) (n = 759)

 

- Adenoma

5

0,7%

 

- Colon Cancer

265

34,9%

 

- Rectal Cancer

20

2,6%

 

- Bladder Cancer

16

2,1%

 

- Brain Cancer

10

1,3%

 

- Breast Cancer

120

15,8%

 

- Endometrial Cancer

20

2,6%

 

- Esophagus Cancer

5

0,7%

 

- Head and neck Cancer

4

0,5%

 

- Kidney Cancer

34

4,5%

 

- Leukemia

21

2,8%

 

- Liver Cancer

9

1,2%

 

- Lung Cancer

53

7,0%

 

- Lymphoma

30

4,0%

 

- Melanoma

19

2,5%

 

- Myeloma

10

1,3%

 

- Other

17

2,2%

 

- Ovarian Cancer

9

1,2%

 

- Pancreas Cancer

21

2,8%

 

- Prostate Cancer

60

7,9%

 

- Stomach Cancer

28

3,7%

 

- Thyroid Cancer

7

0,9%