Fig. 3: Clonal evolution during treatment. | BJC Reports

Fig. 3: Clonal evolution during treatment.

From: Genomic profiling and clinical utility of circulating tumor DNA in metastatic prostate cancer: SCRUM-Japan MONSTAR SCREEN project

Fig. 3

a Change of tumor fraction in paired ctDNA at pre-treatment and post-treatment from same patients (n = 46). Blue bar, metastatic castration-sensitive prostate cancer; red bar, metastatic castration-resistant prostate cancer. b Correlation of blood tumor mutation burden (bTMB) in paired ctDNA at pre-treatment and post-treatment from matched patients (n = 46). c Venn diagram on of concordance and discordance of genomic alterations in ctDNA between pre-treatment and post-treatment from matched patients (n = 46). d Altered genes with frequency of over 5% in ctDNA at pre-treatment or post-treatment from matched patients (n = 46). The data on tumor tissue genotyping was available in patients in red.

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