Table 2 Loss of vimentin in preoperative specimens in endometrioid and FIGO stage 1 tumors associated with clinicopathological features of aggressive disease.

From: Loss of vimentin expression in preoperative biopsies independently predicts poor prognosis, lymph node metastasis and recurrence in endometrial cancer

 

Endometrioid patients

FIGO 1 patients

Variable

Vim pos n (%)

Vim loss n (%)

P-value

Vim pos n (%)

Vim loss n (%)

P-value

Number of patients

1134

66

 

1051

74

 

Age

  

0.011

  

0.023

<66

595 (96)

24 (4)

 

541 (95)

28 (5)

 

≥66

539 (93)

42 (7)

 

510 (92)

46 (8)

 

FIGO-09 stagea

  

0.063

   

I–II

1009 (95)

53 (5)

    

III–IV

124 (91)

12 (9)

    

Histologic gradea

  

0.529

  

<0.001

Grade 1

535 (95)

26 (5)

 

493 (95)

24 (5)

 

Grade 2

422 (93)

32 (7)

 

337 (94)

22 (6)

 

Grade 3

165 (95)

8 (5)

 

213 (88)

28 (12)

 

Histologic type

     

<0.001

Endometrioid

   

937 (95)

49 (5)

 

Serous

   

61 (82)

13 (18)

 

Clear cell

   

16 (70)

7 (30)

 

Carcinosarcoma

   

27 (84)

5 (16)

 

Undifferentiated

   

10 (100)

0 (0)

 

Myometrial infiltrationa

  

<0.001

  

<0.001

<50%

695 (97)

22 (3)

 

740 (96)

35 (4)

 

≥50%

375 (91)

37 (9)

 

298 (89)

37 (11)

 

Recurrencea,b

  

<0.001

  

<0.001

No

943 (96)

43 (4)

 

917 (95)

52 (5)

 

Yes

148 (89)

19 (11)

 

124 (85)

21 (15)

 

Lymph node metastasisa

  

0.024

   

No

700 (95)

37 (5)

    

Yes

72 (89)

9 (11)

    
  1. FIGO International Federation of Gynaecologist and Obstetrics, n number of patients, Vim pos positive vimentin expression, Vim loss loss of vimentin expression.
  2. Positive: SI 1–9, Loss: SI 0.
  3. Statistically significant P-values (<0.05) are bold.
  4. Endometrioid patients: aData missing on FIGO stage for 2 patients, histologic grade for 12 patients, myometrial infiltration for 71 patients, and lymph node metastatic status for 382 patients. b47 patients with metastasis at primary treatment is censored.
  5. FIGO 1 patients: aData missing on histologic grade for 8 patients and myometrial infiltration for 15 patients. b11 patients with metastasis at primary treatment is censored.
Back to article page