Table 2 Some key advantages and disadvantages of the most common methods of SLN formulation.
From: Solid lipid nanoparticles in pancreatic cancer treatment
Formulation method | Advantages | Disadvantages | Ref |
|---|---|---|---|
Ultrasonication | - Simple and accessible at lab scale - Free from organic solvents | - Potential metal contamination - Wide size distribution | |
Solvent-based methods | - Low cost with no expensive apparatus - No risk of thermal degradation | - Residual solvents may cause toxicities - Low energetic cost | |
Hot/Cold-high pressure homogenisation | - Expensive and energy intensive - Easily scalable | - High polydispersity - May cause thermal degradation |
