Fig. 3: Objectives responses according to RECIST 1.1. criteria.

a Best radiological response observed to treatment as per cohort. b Spider plot of radiological response. Tumour responses were measured and values show percent change of the sum of target lesion diameters from the baseline measurements of each measurable tumour. Changes in target tumour diameter for patients included in cohort 1, cohort 2, cohort 3 and cohort 4 are represented in blue, green, yellow and red respectively.