Table 1 Background data and ctDNA status at the initial assessment after surgery (n = 40).
Factors | Category | ctDNA negative (n = 20) | ctDNA positive (n = 20) | P value |
|---|---|---|---|---|
Age, median | 69.5 [50–79] | 64.5 [49–83] | 0.28 | |
Sex (male) | Female | 1 (5%) | 7 (35%) | 0.04 |
Male | 19 (95%) | 13 (65%) | ||
Location | Ut | 4 (20%) | 7 (35%) | 0.39 |
Mt | 11 (55%) | 9 (45%) | ||
Lt | 3 (15%) | 4 (20%) | ||
EGJ | 2 (10%) | 0 | ||
Histology | Adeno | 4 (20%) | 0 | 0.11 |
SCC | 16 (80%) | 20 (100%) | ||
Pathological T Stage | T1 | 9 (45%) | 10 (50%) | 0.88 |
T2 | 3 (15%) | 2 (10%) | ||
T3 | 8 (40%) | 8 (40%) | ||
Pathological N Stage | N0 | 9 (45%) | 10 (50%) | 0.01 |
N1 | 9 (45%) | 2 (10%) | ||
N2 | 1 (5%) | 8 (40%) | ||
N3 | 1 (5%) | 0 | ||
Pathological Stage | 0, IA, IB | 5 (25%) | 6 (30%) | 0.61 |
IIA, IIB | 8 (40%) | 5 (25%) | ||
IIIA, IIIB | 5 (25%) | 8 (40%) | ||
IVA, IVB | 2 (10%) | 1 (5%) | ||
NAC | No | 7 (35%) | 8 (40%) | 1.00 |
Yes | 13 (65%) | 12 (60%) | ||
Adj | No | 15 (75%) | 18 (90%) | 0.41 |
Yes | 5 (25%) | 2 (10%) | ||
R0 resection | No | 0 | 3 (15%) | 0.23 |
Yes | 20 (100%) | 17 (85%) | ||
LN dissection | Two-field | 13 (65%) | 13 (65%) | 1.00 |
Three-field | 7 (35%) | 7 (35%) | ||
TMB (tumor tissue) | 33.2 [15.7–97.4] | 43.3 [14.6–69.0] | 0.22 | |
TMB (pre-therapy plasma) | 9.2 [0.4–12.3] | 8.6 [1.5–12.3] | 0.93 | |
