Fig. 4: Effects of AMPH on rCPT performance. | NPP—Digital Psychiatry and Neuroscience

Fig. 4: Effects of AMPH on rCPT performance.

From: Time-on-task-related decrements in performance in the rodent continuous performance test are not caused by physical disengagement from the task

Fig. 4: Effects of AMPH on rCPT performance.

A AMPH at 0.6 mg/kg attenuates the TOT-dependent decrease in d’ in male mice. A triangle (▲) indicates significant pos hoc results between 0.6 mg/kg and vehicle. An asterisk indicates statistical significance of main effect of time bin or treatment. B Female mice showed significant increases in C and decreases in HR and FAR at the highest dose (1 mg/kg). Further post hoc analysis also showed these changes mainly happened during the first three time bins. Data are shown as mean ± SEM. n = 15 males and 7 females. An asterisk (** or ***) indicates statistical significance of main effect of time bin or treatment. A hash (#) indicates significant effect of 1 mg/kg comparing to vehicle. A circle (•) indicates a significant effect of 0.6 mg/kg comparing to vehicle. **p < 0.01, ***p < 0.001, #p < 0.05, ##p < 0.01, ###p < 0.001, • p < 0.05, •• p < 0.01.

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