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Biochemical sensing

A search-and-branch mechanism for microtubule sensing

An engineered confinement device reveals how the microtubule cytoskeleton senses and adapts to its environment by harnessing the interplay between catastrophe instability and branching nucleation.

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Fig. 1: Boundary sensing and self-organization of branching microtubule networks in confined microchannels.
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References

  1. Gudimchuk, N. B. & McIntosh, J. R. Nat. Rev. Mol. Cell Biol. 22, 777–795 (2021).

    Article  CAS  PubMed  Google Scholar 

  2. Minc, N., Burgess, D. & Chang, F. Cell 144, 414–426 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Mitchison, T. & Kirschner, M. Nature 312, 237–242 (1984).

    Article  CAS  PubMed  Google Scholar 

  4. Janson, M. E., de Dood, M. E. & Dogterom, M. J. Cell Biol. 161, 1029–1034 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Zaferani, M., Song, R., Wingreen, N. S., Stone, H. A. & Petry, S. Nat. Chem. Eng. https://doi.org/10.1038/s44286-025-00264-0 (2025).

    Article  Google Scholar 

  6. Petry, S. et al. Cell 152, 768–777 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Takagi, J. et al. Dev. Cell 49, 267–278 (2019).

    Article  CAS  PubMed  Google Scholar 

  8. Dogterom, M. & Koenderink, G. H. Nat. Rev. Mol. Cell Biol. 20, 38–54 (2019).

    Article  CAS  PubMed  Google Scholar 

  9. Bieling, P. et al. Cell 164, 115–127 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Correspondence to Ryota Sakamoto or Yusuke T. Maeda.

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Sakamoto, R., Maeda, Y.T. A search-and-branch mechanism for microtubule sensing. Nat Chem Eng 2, 537–538 (2025). https://doi.org/10.1038/s44286-025-00276-w

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