Table 1 Patient characteristics
From: Antidepressant use during pregnancy and the risk of preterm birth – a cohort study
Cohort characteristics | All births | Term (≥37w) | Preterm (<37w) | |
|---|---|---|---|---|
Births (N,%) | 216,070 | 198,455 (91.8%) | 17,615 (8.2%) | |
Mothers (N,%) | 176,866 | 163,906 (92.7%) | 16,946 (9.6%) | |
Socio-demographic | Age at pregnancy | 29.8 (5.8) | 29.8 (5.8) | 29.9 (6.1) |
Pre-pregnancy BMI | 24.5 [21.7,28.7] | 24.5 [21.7,28.7] | 24.7 [21.6,29.0] | |
Smoker (anytime) | 74,350 (34.4%) | 67,663 (34.1%) | 6687 (38.0%) | |
Alcohol abuse | 1251 (0.6%) | 1110 (0.6%) | 141 (0.8%) | |
Drug abuse | 396 (0.2%) | 340 (0.2%) | 56 (0.3%) | |
Deprivation index quantile | 2.84 (1.4) | 2.83 (1.4) | 2.97 (1.4) | |
Medical history | Diabetes Mellitus | 2633 (1.2%) | 2095 (1.1%) | 538 (3.1%) |
Hypertensive disorder | 3855 (1.8%) | 3323 (1.7%) | 532 (3.0%) | |
Heart disease | 2427 (1.1%) | 2189 (1.1%) | 238 (1.4%) | |
Asthma | 33,856 (15.7%) | 31,073 (15.7%) | 2783 (15.8%) | |
Renal impairment | 457 (0.2%) | 381 (0.2%) | 76 (0.4%) | |
Obesity | 4987 (2.3%) | 4537 (2.3%) | 450 (2.6%) | |
Mental health history | Depression anytime | 53,089 (24.6%) | 48,121 (24.2%) | 4968 (28.2%) |
Recent depression (1 yr) | 14,652 (6.8%) | 13,212 (6.7%) | 1440 (8.2%) | |
Anxiety anytime | 35,087 (16.2%) | 32,027 (16.1%) | 3060 (17.4%) | |
Recent anxiety (1 yr) | 8067 (3.7%) | 7318 (3.7%) | 749 (4.3%) | |
Medications (1 yr before pregnancy) | Antibacterials for systemic use (J01) | 93,927 (43.5%) | 85,801 (43.2%) | 8126 (46.1%) |
Antiinflamatory and antirheumatic (M01) | 32,722 (15.1%) | 29,712 (15.0%) | 3010 (17.1%) | |
Beta blocking agents (C07) | 4967 (2.3%) | 4463 (2.2%) | 504 (2.9%) | |
Drugs for acid related disorders (A02) | 14,940 (6.9%) | 13,524 (6.8%) | 1416 (8.0%) | |
Drugs for obstructive airway disease (R03) | 23,840 (11.0%) | 21,718 (10.9%) | 2122 (12.0%) | |
Opioids (N02A) | 8879 (4.1%) | 7924 (4.0%) | 955 (5.4%) | |
Mental health medications (1 yr before pregnancy) | Antidepressants (N06A) | 26,285 (12.2%) | 23,634 (11.9%) | 2651 (15.0%) |
SSRI (N06AB) | 20,544 (9.5%) | 18501 (9.3%) | 2043 (11.6%) | |
NSMRI (N06AA) | 5669 (2.6%) | 5026 (2.5%) | 643 (3.7%) | |
Other (N06AX) | 3193 (1.5%) | 2820 (1.4%) | 373 (2.1%) | |
Psycholeptics (N05) | 15,104 (7.0%) | 13,541 (6.8%) | 1563 (8.9%) | |
Anxiolytics (N05B) | 5810 (2.7%) | 5228 (2.6%) | 582 (3.3%) | |
Delivery | Gestation week | 40.0 [38.9,41.0] | 40.0 [39.0,41.0] | 35.0 [32.3,36.0] |
Cesarean section | 12,218 (5.7%) | 10,631 (5.4%) | 1587 (9.0%) | |
